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Practical Aspects of Small Molecule Drug Discovery

Wellcome Trust

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Course Description

Programme A growing number of investigators in leading research institutions and small and medium-sized companies are expanding from their strength in disease biology into early-stage drug discovery. However, this move requires successfully combining the disciplines of biochemistry, medicinal chemistry, pharmacokinetics and pharmacology, the breadth of which can present organisational, knowledge and competence challenges for institutions and investigators. This residential course aims to give researchers of any discipline a broad introduction into the theoretical, practical and organisational aspects of small molecule drug discovery. Each topic will include a lecture together with discussion sessions or case histories to develop key aspects highlighted in the lectures. In addition there will be practical sessions to illustrate the beginnings of drug discovery programmes, including the production of project plans and milestones, compound progression criteria and scientific strategy based on screening results. Topics will include : project management and organisation of multi-disciplinary projects target product profiles target validation Hit discovery options screening set curation, storage and quality control screening cascades, assay development and quality control principles of compound optimisation in silico approaches to drug design, screening and ADMET intellectual property strategy professional and funding body fundraising and project exit strategies an introduction to preclinical and clinical development. Course director Professor Paul Wyatt (Drug Discovery Unit, University of Dundee, UK) Guest lecturers A prestigious panel of guest lecturers from industry, academia and established not-for-profit organisations will be assembled for the course. Last year's lecturers included senior representatives from: Pfizer GlaxoSmithKline Merck, Sharp & Dohme AstraZeneca Medical Research Council University of Dundee Cancer Research UK BioFocus DPI Tukan Partners Ltd Organon Laboratories Ltd Lectus Therapeutics Ltd Astex Therapeutics Ltd Melior Discovery GF Associates Cost The course tuition fees are subsidised by the Wellcome Trust for scientists based in academic institutions anywhere in the world. This is a residential course, without exception, and there is a registration fee of ?770 towards board and lodging for academic applicants. The fee for commercial (non-academic) applicants is ?1800. Bursaries Limited bursaries are available for academic or clinical applicants from non-commercial organisations (50 per cent of fee) and are subject to open competition. Applications Applicants will be required to complete an application form containing their CV together with a 300-word outline of the relevance of the course to their research. Please note that documentation supporting their application will be required from the applicant's supervisor/head of department. Bursaries for Wellcome Trust Advanced Courses The Wellcome Trust subsidises all courses and workshops, so there are no tuition fees. The ?course fee' for the UK courses (held at Hinxton) covers on-site accommodation and food for the duration of the course. Bursaries are available to assist with UK course fees, but not travel costs. We are committed to building scientific capacity in developing countries and are expanding the number of courses and workshops run outside of the UK (?overseas' courses). There is no fee for these courses and bursaries are available for travel, sustenance and accommodation. Please see below for full details. UK Courses (held at the Wellcome Trust Genome Campus in Hinxton) A limited number of bursaries are available for each course. These are awarded by the selection committee according to merit. The bursary usually covers 50 per cent of the course fee, though in exceptional circumstances an application for the total course fee may be considered. Where there are many bursary applications, the selection committee may issue smaller amounts. We cannot a

Programme A growing number of investigators in leading research institutions and small and medium-sized companies are expanding from their strength in disease biology into early-stage drug discovery. However, this move requires successfully combining the disciplines of biochemistry, medicinal chemistry, pharmacokinetics and pharmacology, the breadth of which can present organisational, knowledge...

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