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Title: Setup of a ?RapidFire Mass Spectrometry? platform for label free enzymatic screening Supervisors: Dr Aur?lie Vassort, Sanofi-Aventis, Toulouse, France Dr Dave Barrett, School of Pharmacy, University of Nottingham, UK Project location: The generic training element of the MRes will take place at the University of Nottingham. The research project itself will be undertaken at Sanofi-Aventis will start no later than three months after registration at the University of Nottingham. Project description The aim of the project is to setup a new ?label free? screening platform termed ?RapidFire Mass Spectrometry?? (RF-MS? sold by Biocius). Label free methods are becoming an important tool in drug discovery since it enables the detection of native compounds without the need for fluorescence, luminescence or radioactivity labeling. Therefore, the RF-MS system is positioned to address intractable targets in expanding therapeutic areas, enabling the direct measurements of historically difficult analytes (lipids, fatty acids, steroids, prostaglandins, non-phosphate protein modifications, anti-infectivesanti-fungals). The RF system samples directly from quenched assay plates into an SPE cartridge, elutes the sample and injects it onto the MS detector (online) for substrate andor product quantification of the enzymatic reaction. The student will initially be involved in (with the help of hisher supervisor) the installation and setup of the platform, and subsequently will participate in the screening of targets of therapeutic interest. The student will have the unique opportunity to work across disciplines and integrate knowledge from analytical chemistry and biochemistry in an innovative and well-equipped environment at Sanofi-Aventis. Students should have a minimum of a 2.1 undergraduate degree in a relevant discipline (chemistry, biochemistry) and have a good knowledge and enthusiasm for analytical chemistry. Previous laboratory or research experience either as part or outside of a university degree is desirable. The ability to speak French is not a requirement. The successful student should be highly motivated, resourceful and have good organizational skills. This studentship provides a three month stipend during the training period at the University of Nottingham and a generous stipend over the remaining nine months from Sanofi-Aventis. In addition, a dedicated association (paid by Sanofi-Aventis) will take care of the administrative work (social security number, bank account, finding an accommodation, pick-up from airport, etc.) and there will also be a meal allowance. This studentship is open to UK or EU citizens. Please note that the student will need to pay University fees of ?3460 from their stipend. Sanofi-Aventis is a global healthcare company focused on patients? needs. The Toulouse site is dedicated to Discovery Research, the first step in the development of a drug. Informal enquiries may be addressed to Dr A Vassort, tel: 0033 534632239, Email: aurelie.vassort@sanofi-aventis.com or to Dr Dave Barrett 0044 115 9515062, email david.barrett@nottingham.ac.uk Applications (preferably by Email), with a detailed CV and the names and addresses of two referees, should be sent to Mrs Christina Macleod, School of Pharmacy, University of Nottingham, Nottingham, UK. Email: christina.macleod@nottingham.ac.uk .

Title: Setup of a ?RapidFire Mass Spectrometry? platform for label free enzymatic screening Supervisors: Dr Aur?lie Vassort, Sanofi-Aventis, Toulouse, France Dr Dave Barrett, School of Pharmacy, University of Nottingham, UK Project location: The generic training element of the MRes will take place at the University of Nottingham. The research project itself will be undertaken at Sanofi-Aventis...

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