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MRes in Drug Discovery and Development: Multidisciplinary Science for Next Generation Therapeutics

Imperial College London

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Course Description

This MRes programme is a one-year stand-alone course that will develop your expertise in multidisciplinary drug discovery research, and provide a deep understanding of the current global state of drug discovery together with radical insights into future directions from leaders in the field. Whilst you will graduate from the course with a solid knowledge of the drug discovery process from emerging technologies and drug target selection through to clinical trials and regulatory aspects, you will also be challenged to develop your own ideas on how to focus academic and industrial research to meet the pressing challenges of drug discovery. At its conclusion you will be ideally placed to undertake PhD studies in collaborative multidisciplinary drug discovery or to apply your knowledge in industry. Course Structure: The course consists of a nine-month interdisciplinary research project, and tuition takes the form of a taught component on drug discovery science, research seminars and group discussion sessions, as well as specialist lectures in transferable skills. Taught modules currently offered include: Module 1 - Introduction ? Standard Drug Discovery Model ? Small molecule drugs ? Biologicals ? Molecular Interactions in Proteins and Enzymes ? What makes a good drug? Module 2 ? The right targets ? Overview on target validation ? Systems Approaches in Drug Discovery ? Chemical Genetics ? Target selection and Biomarkers ? Protein modelling strategies Module 3 ? The right drugs ? In silico drug design ? Structural biology for drug design ? Bioanalytical Techniques ? High throughput screening ? High content screening ? Re-purposing drugs ? Fragment-based drug design ? Whole animal imaging ? Gene therapy Module 4 ? In the Clinic ? Getting drugs to market ? Financing and protecting drug discovery ? Designing Clinical Trials ? Current therapeutic challenges in... - Infection - Cardiovascular disease - Cancer - Inflammation and COPD - Neurodegenerative diseases Module 5 ? Forming an opinion ? Keynote lectures from high profile guest speakers covering past, future, and frontiers of the field Multidisciplinary research project: The major component of the course is an 8-month long multidisciplinary research project on drug discovery and development. You will select a research project from a range of proposals submitted by collaborating staff, and jointly supervised by at least one physical scientist and one scientist from the biomedical sciences or industry the lead supervisor will be based at Imperial College. The projects are based entirely in the research laboratories of the supervisors, allowing you to benefit from interaction with postdoctoral and postgraduate researchers from each discipline. Satisfactory progress is monitored by a mid-term progress report completed by you and your supervisors. The course directors will regularly request feedback regarding your project progress, logistics and effectiveness of split site working, and will offer additional support whenever necessary.

This MRes programme is a one-year stand-alone course that will develop your expertise in multidisciplinary drug discovery research, and provide a deep understanding of the current global state of drug discovery together with radical insights into future directions from leaders in the field. Whilst you will graduate from the course with a solid knowledge of the drug discovery process from emerging...

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