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RESEARCH AREAS MPhil supervision is normally available in the following areas: Cancer genetics and genome instability: research includes a major clinical trial for chemoprevention of colon cancer genetic analyses of neuroblastoma susceptibility research into Wilms Tumour, a childhood kidney cancer and studies on cell cycle regulation and genome instability. Cardiovascular genetics and development: we use techniques of high-throughput genetic analyses to identify mechanisms whereby genetic variability between individuals contributes to the risk of developing cardiovascular disease. We also use mouse and zebrafish and stem cell models to understand the ways in which particular gene families genetic and environmental factors are involved in the normal and abnormal development of the heart and blood vessels. Complex disease and quantitative genetics: large-scale studies into the genetic basis of common diseases with complex genetic causes, for example autoimmune disease, complex cardiovascular traits and renal disorders, is a major theme. We are also developing novel statistical methods and tools for analysing this genetic data. Gene regulation in normal development and disease: research into how gene expression is controlled during development and misregulated in diseases, including the roles of transcription factors, RNA that binding proteins and the signalling pathways that, control these. Genetics of neurological disorders: Identification of genes that in isolation can cause neurological disorders, molecular mechanisms and treatment of neurometabolic disease, complex genetics of common neurological disorders including Parkinson s disease and Alzheimer s disease. The genetics of epilepsy. Developmental genetics: study of genes known or suspected to be, involved in malformations found in newborn babies. These include normal and abnormal development of the face, brain, heart, muscle and kidney system, using knockout mice and zebrafish as laboratory models. Mitochondrial disease: investigation of the role of mitochondria in human disease, nuclear-mitochondrial interactions in disease, the inheritance of mitochondrial DNA heteroplasmy, and mitochondrial function in stem cells. Kidney genetics and development: kidney research focuses on atypical haemolytic uraemic syndrome (aHUS), vesicoureteric reflux (VUR), cystic renal disease and nephrolithiasis to study renal genetics. The discovery that aHUS is a disease of complement dysregulation has led to a specific interest in complement genetics. Stem cell biology: research on human embryonic stem (ES) cells, germline stem cells and somatic stem cells. ES cell research is aimed at understanding stem cell pluripotency, self-renewal, survival and epigenetic control of differentiation and development, including the functional analysis of genes involved in germline stem cell proliferation and differentiation. Somatic stem cell projects include programmes on umbilical cord blood stem cells, haematopoietic progenitors, and limbal stem cells. RESEARCH DEGREE TRAINING AND SKILLS DEVELOPMENT Our Medical Sciences Graduate School has a thriving postgraduate research culture, with additional support for international students. We have an excellent record for timely PhD submission, provide training in professionalkey skills and research techniques and support personal development. TYPICAL FUNDING Funded PhD positions are usually advertised on the funding database and the Newcastle Biomedicine website - http:www.ncl.ac.ukbiomedicinepostgradfunding%20 International students ? own government British Council University scholarships. For more information about funding opportunities please see http:www.ncl.ac.ukpostgraduatefunding HOW TO APPLY For the quickest and easiest way to apply please visit our postgraduate online application site http:www.ncl.ac.ukpostgraduateapply

RESEARCH AREAS MPhil supervision is normally available in the following areas: Cancer genetics and genome instability: research includes a major clinical trial for chemoprevention of colon cancer genetic analyses of neuroblastoma susceptibility research into Wilms Tumour, a childhood kidney cancer and studies on cell cycle regulation and genome instability. Cardiovascular genetics and...

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Entry Requirements

An upper-second-class Honours degree, or international equivalent, in a science or medicine related subject. Applicants whose first language is not English require IELTS 6.5, TOEFL 90 (Internet-based), Pearson's PTE Academic Test 62 or equivalent. Our Iion and Itemalue+oSn++???A????#? ?+???????????????????????????????????+S?++??????,???@#iItem????????????????? ?????

An upper-second-class Honours degree, or international equivalent, in a science or medicine related subject. Applicants whose first language is not English require IELTS 6.5, TOEFL 90 (Internet-based), Pearson's PTE Academic Test 62 or equivalent. Our Iion and Itemalue+oSn++???A????#?...

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