Loader
logo
Course Image

Course Description

This course is intended to provide the students with the understanding of the fundamental workings of neuron and the detailed molecular mechanisms by which these can be disrupted in neuronal diseases. The lectures will be divided into two parts. In Part A (Lectures 1-8), an introduction to Neurons will be given which will cover their Structures, Development, Molecular Constituents and Functions. In Part B (Lectures 9-16), the fundamental mechanisms of dysfunction will be discussed in the context of specific neuronal diseases. Model animal systems as well as state-of-the-art techniques will be covered within each of these lectures in their functional context. This will allow emphasising the advantages and disadvantages of techniques used in neuroscience research in terms of applicability, information content, and technical aspects, allowing students to critically evaluate published experiments and design their own meaningful experiments. Specific modern techniques used in neuroscience will be demonstrated in laboratory settings. A list of projects with short descriptions is available here (web site from Mikhail). Project titles include: ? Centrosome proteins and schizophrenia ? Characterisation of a model system for gonadotropin-releasing hormone signalling ? Development of smart contrast reagents for MRI diagnosis of Alzheimer?s Disease ? Epileptic drugs and cell signalling ? Glutamate receptor triggered neuronal cell death ? Glutamate receptor pharmacology and intracellular synaptic proteins ? Ischaemic white matter lesions in human brain ? Investigation of the role of oncogenes in brain development ? Investigating the role of novel dopamine receptor interacting proteins in neuropsychiatric disorders ? Lipid signalling as a therapeutic target in a simple model system ? Modulation by cannabinoids of peripheral neurotransmission ? Molecular analysis of the role of the centrosome in neurogenesis. ? Neuropathology of an aged rodent model of stroke ? PDZ-binding peptides that prevent excitotoxic neuronal death ? Regulation of cytoskeletal rearrangements during memory formation ? Sex, smell and cancer: the common molecular signalling pathways involved in the development of Kallmann syndrome and brain tumours ? Signalling from the synapse to the nucleus calmodulin ? The mechanisms of activation and autophosphorylation of alpha-CaMKII http:www.sgul.ac.ukstudentspostgraduatedegreesmres.cfm

This course is intended to provide the students with the understanding of the fundamental workings of neuron and the detailed molecular mechanisms by which these can be disrupted in neuronal diseases. The lectures will be divided into two parts. In Part A (Lectures 1-8), an introduction to Neurons will be given which will cover their Structures, Development, Molecular Constituents and Functions....

Read More

Related Courses