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Course Description

The Clinical Genomics MSc is a flagship partnership between the NHS and St George’s, University of London. It is aimed at clinical geneticists in training, delivering bespoke education and training, and recognising the unique needs of an expert workforce in the genomics era.

The use of genomic data is revolutionising the NHS and transforming patient diagnosis and treatment. The Clinical Genomics MSc will equip you with the ability and understanding to interpret genomic data when making clinical management decisions. It will also give you the opportunity to undertake a research project and extend your learning to areas of genomics that are of particular interest to you. You will develop the knowledge, skills and attributes that will allow you to disseminate your expert knowledge through the wider medical workforce.

The Clinical Genomics MSc comprises:

  1. Four core modules from the PGCert ICAG (60 credits)
  2. A research project, organised by you and flexibly arranged to allow you to undertake it at your base hospital, in Genomics England or at a suitable alternative location (60 credits)
  3. Four modules chosen from a range of optional modules that are applicable to Clinical Genetics and reflect your interests (60 credits)

The Clinical Genomics MSc is a flagship partnership between the NHS and St George’s, University of London. It is aimed at clinical geneticists in training, delivering bespoke education and training, and recognising the unique needs of an expert workforce in the genomics era. The use of genomic data is revolutionising the NHS and transforming patient diagnosis and treatment. The...

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Course Content

Clinical Genomics MSc consists of eight modules (four core and four optional) and a research project. 

Core modules 

Understanding genetic technologies

This module will equip you with knowledge of the principles behind commonly used molecular techniques and how to apply them. You will learn how to evaluate which laboratory investigations are most suitable for a given clinical scenario and to critically review the processes used in issuing a laboratory report, from checking samples to issuing a diagnostic report. You will also learn how to design a panel of genes for analysis using next-generation sequencing technologies applicable to a specific clinical phenotype.

Clinical interpretation of genomic data

You will learn how to analyse the key features of a genetic variant which affect the prior likelihood of pathogenicity. You will understand how to critically examine the clinical context within which a genetic variant will be interpreted. This module will teach you how to apply in silicovariant analysis tools to evaluate genetic variants, equipping you with the skills to critically evaluate the report generated by in silicovariant analysis tools. By the end of the module you will be able to demonstrate the interrogation of population level genomic databases with respect to a specific genetic variant alongside the interrogation of mutation databases with respect to a specific genetic variant.

Communication of genetic information and ethics

This module will teach you how to communicate effectively and sensitively to patients and their families about complex genetic data and variants of unknown significance. It will allow you to critically evaluate the ethical issues surrounding consent for genetic testing with an understanding and explanation of incidental findings. You will evaluate the ethical considerations of genetic testing and be able to formulate cogent arguments for and against testing in specific clinical scenarios.

Personal and professional development portfolio

In this module you will assemble a portfolio that demonstrates learning and progression in the application of genetic technologies, the interpretation of genomic data, and the communication of complex genetic information to patients. You will demonstrate application of the approaches undertaken in the clinical interpretation of genomic data, and will critically appraise the medical literature relevant to the interpretation of genetic data. Alongside this you will reflect on the effect of genetic test results on the patient and other healthcare professionals and on your communication skills when imparting complex genetic information to patients/families and directed literature. You will finally propose and justify your approaches to continuing professional development.

Research project

You will: select an area of interest; develop a research question and identify an appropriate method to answer that question; undertake a research project; and present your findings. You will be allocated a supervisor for your project who will contribute background knowledge on your subject and methodological expertise to support you throughout the module. This module is flexible but must be arranged by you.

Clinical Genomics MSc consists of eight modules (four core and four optional) and a research project.  Core modules  Understanding genetic technologies This module will equip you with knowledge of the principles behind commonly used molecular techniques and how to apply them. You will learn how to evaluate which...

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Assessment Methods

The assessments have been designed to reflect the knowledge, skills and attributes articulated in the programme. Each module will have its own discrete assessment specifications related to the intended educational aims and learning outcomes of the module mapped to the programme outcomes.

For all taught modules, you will be assessed by up to two summative assessments. Formative assessment will be provided by regular meetings with your educational/laboratory supervisor. Each assessment has specific assessment criteria which will be published in the student handbook. Summative assessments include, for example, oral presentations, written assignments, which will be double (blind) marked by trained assessors, an online multiple choice question (MCQ) examination, and role play. The research module will be assessed through supervisor feedback and a written report.

The assessments have been designed to reflect the knowledge, skills and attributes articulated in the programme. Each module will have its own discrete assessment specifications related to the intended educational aims and learning outcomes of the module mapped to the programme outcomes. For all taught modules, you will be assessed by up to two summative assessments. Formative...

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